INCORPORATION OF ALPHA2- PLASMIN INHIBITOR INTO PLASMA CLOTS OF HEALTHY CONTROLS AND PATIENTS WITH VENOUS THROMBOEMBOLISM

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dc.contributor.advisorKatona, Éva
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Laboratóriumi Medicina Intézet
dc.contributor.authorDauda, Marriam Akua Amprofua
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2024-05-27T10:46:21Z
dc.date.available2024-05-27T10:46:21Z
dc.date.created2023-03-31
dc.description.abstractAlpha2-plasmin inhibitor (A2PI) is the main physiological inhibitor of plasmin. In the final phase of coagulation, activated factor XIII (FXIIIa) cross-links A2PI to fibrin and it has been shown that only cross-linked A2PI can efficiently inhibit fibrinolysis. After secretion into the plasma, full length A2PI contains a C-terminal plasminogen-binding site (PB-A2PI), which is lost due to cleavage by an as yet unknown protease. The truncated form (NPB-A2PI) remains enzymatically active, but it is a slow plasmin inhibitor. FXIIIa primarily cross-links PB-A2PI to fibrin. The binding of the truncated form to the clot and the effect of the ratio of the two C-terminal forms on the incorporation of PB-A2PI have not yet been investigated in detail. The study aims to investigate the incorporation of PB-A2PI and NPB-A2PI into the plasma clots of controls and patients with venous thromboembolism (VTE).
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent25
dc.identifier.urihttps://hdl.handle.net/2437/370372
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectvenous thromboembolism
dc.subjectalpha2-plasmin inhibitor
dc.subjectplasma clots
dc.subject.dspaceMedicine
dc.titleINCORPORATION OF ALPHA2- PLASMIN INHIBITOR INTO PLASMA CLOTS OF HEALTHY CONTROLS AND PATIENTS WITH VENOUS THROMBOEMBOLISM
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