New advancements in anticoagulation therapy

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorRabinovich, Yakov
dc.contributor.departmentDE--Egészségügyi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intenzív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2019-01-30T10:01:49Z
dc.date.available2019-01-30T10:01:49Z
dc.date.created2018-05-22
dc.description.abstractToday anti-coagulation is the mainstay therapy of many diseases, chiefly stroke prevention in patients who are suffering from non-valvular atrial fibrillation and prophylaxis of venous thromboembolism. Vitamin K antagonists (VKA) such as warfarin are being used for decades. VKA proved to be very cost-effective solution that when combined with vast body of experience made them one of the more prescribed drugs in the global market. In the begging of the last decade a new group of drugs was introduced, the direct oral anticoagulant or DOAC for short. DOACs improved on the efficacy and safety with a predictable effect that doesn’t requires weekly monitoring. However, physicians are still hesitant in using these new agents, lack of familiarity and the absence of a reliable reversal strategy are perhaps the leading contributors. It was only recently that a specific reversal agent was introduced (Idarucizumab for dabigatran). Availability of reversal agent have the potential to change the guidelines recommendations for the use of DOAC over VKA. With more reversal agents in development, DOAC popularity among physicians and patient is bound to grow, our familiarity with these agents need to grow accordingly.hu_HU
dc.description.correctorSZG
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent37hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/263380
dc.language.isoenhu_HU
dc.subjectvitamin K antagonistshu_HU
dc.subjectanti-coagulantshu_HU
dc.subjectidarucizumabhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleNew advancements in anticoagulation therapyhu_HU
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