Tissue transglutaminase regulates mitochondrial functions in Sz95 sebocytes

dc.contributor.advisor	Fedor-Lénárt, Kinga
dc.contributor.advisordept	Általános Orvostudományi Kar::Bőrgyógyászati Tanszék
dc.contributor.author	Yousef, Heba
dc.contributor.department	DE--Általános Orvostudományi Kar
dc.date.accessioned	2024-02-14T10:20:37Z
dc.date.available	2024-02-14T10:20:37Z
dc.date.created	2024
dc.description.abstract	TG2 deficiency in sebaceous glands leads to lipid accumulation and reduced autophagy, prompting investigation into mitochondrial dysfunction. Using CRISPR/Cas9, WT and TG2 KO sebocyte cell lines were compared, revealing differential expression of mitochondria-associated genes and decreased levels of oxidative phosphorylation complexes in TG2 KO cells. Elevated ROS levels further confirmed mitochondrial impairment, suggesting defective energy production pathways in TG2-deficient cells, warranting further research into disease implications and therapeutic strategies.
dc.description.course	általános orvos
dc.description.courselang	angol
dc.description.degree	egységes, osztatlan
dc.format.extent	48
dc.identifier.uri	https://hdl.handle.net/2437/366319
dc.language.iso	en
dc.rights.access	Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subject	sebosytes
dc.subject	acne vulgaris
dc.subject	mitochandria
dc.subject.dspace	Chemistry::Biochemistry
dc.subject.dspace	Medicine::Dermatology
dc.title	Tissue transglutaminase regulates mitochondrial functions in Sz95 sebocytes

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