Targeted-release budesonide in immunoglobulin A nephropathy; a mini-review

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dc.contributor.authorToumaj, Shiva
dc.contributor.authorAlimohammadi, Shahrzad
dc.contributor.authorGhasemi, Maryam
dc.contributor.authorShayanpour, Shokouh
dc.contributor.authorAlimohammadi, Shahrzad (1991-) (Gyógyszerész)
dc.contributor.authorAlimohammadi, Shahrzad (1991-) (Gyógyszerész)
dc.contributor.submitterdepImmunológiai Intézet -- 18
dc.contributor.submitterdepÁOK
dc.contributor.submitterdepDebreceni Egyetem
dc.contributor.submitterdepDebreceni Egyetem - Molekuláris Orvostudomány Doktori Iskola
dc.date.accessioned2023-07-18T13:27:02Z
dc.date.available2023-07-18T13:27:02Z
dc.date.oa2023-08-07
dc.date.updated2023-07-18T13:27:02Z
dc.description.abstractImmunoglobulin A nephropathy is the most common kind of primary glomerulonephritis worldwide and one of the main causes of renal failure. Systemic corticosteroid therapy may protect against renal deterioration in IgA nephropathy; however, it is not often advised for long-term treatment due to possible side effects. Recent studies present promising results of the new targeted-release formulation of budesonide that delivers the drug to the distal ileum to reduce side effects for patients with IgA nephropathy. In this paper, we highlighted the potential benefits of budesonide as a treatment option for IgA nephropathy and the need for additional studies to confirm its effectiveness. The lack of alternative treatments to prevent renal deterioration without other systemic side effects motivated us to gather relevant information to fill this gap. In this brief overview, we have reviewed some of the most recently published studies regarding how budesonide protects against IgA nephropathy. Studies reveal that budesonide might significantly decrease proteinuria, hematuria, and creatinine level while maintaining normal renal function. Though, a limited number of trials have been established to date, and further investigations are needed to confirm the benefit of the new targeted-release budesonide in treating IgA nephropathy
dc.description.correctorkzs
dc.identifier.citationJournal of Nephropharmacology. -12 : 2 (2023), p. 1-8 (cikkazonosító)e10605. -J Nephropharmacol. -2345-4202
dc.identifier.doi10.34172/npj.2023.10605
dc.identifier.issn2345-4202
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113522
dc.identifier.urihttps://hdl.handle.net/2437/357662
dc.identifier.urlhttps://jnephropharmacology.com/Article/npj-10605
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerszerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otherBudesonide; Corticosteroids; End-stage kidney disease; Glomerulonephritis; IgA nephropathy; Immunosuppressive therapy
dc.titleTargeted-release budesonide in immunoglobulin A nephropathy; a mini-review
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