Antibody-Mediated Rejection and Mono-Polyclonal Antibody Therapies in Kidney Transplantation

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorYilmaz, Tuba
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.date.accessioned2017-01-06T08:01:03Z
dc.date.available2017-01-06T08:01:03Z
dc.date.created2015-09-04
dc.description.abstractMost common solid organ transplantation is kidney transplantation which is preferred for all end-stage renal disease (ESRD), as it offers improve quality of life and survival. If chronic kidney disease (CKD) stage 4 (GFR<30ml/min/1.73m2), transplantation should be discussed.Kidney transplant rejections are classified into T-cell mediated (acute cellular rejection) and antibody mediated rejection (AMR). 3 type of AMR; hyperacute (occurs due to DSA present in high titer within minutes. Hemorrhagic cortical necrosis, neutrophil and platelet accumulation occurs in glomeruli and peritubular capillary), acute (suddenly onset of graft dysfunction that often arise in first weeks after transplantation. It is characterized by presence of DSA, impaired urine output, C4d deposition in peritubular capillary), chronic (It is slow, progressive loss of graft function that usually develops 1 year after transplantation. Aim of treatment AMR: Antibody removal by plasmapheresis, immunoadsorbtion, intravenous immunoglobulin, splenectomy; anti-B-cell therapy by rituximab, IVIG; antiplasma cell therapy bortezomib; anti-T-cell therapy by antithymocyte globulin; terminal-complement pathway inhibitor by eculizumab.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent42hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/233634
dc.language.isoenhu_HU
dc.rightsNevezd meg! - Ne add el! - Ne változtasd! 2.5 Magyarország*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/hu/*
dc.subjectKidney transplantationhu_HU
dc.subjectantibody-mediated rejection
dc.subjectplasmapheresis
dc.subjectIVIG
dc.subjectPolyclonal antibody
dc.subjectmonoclonal antibodies
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleAntibody-Mediated Rejection and Mono-Polyclonal Antibody Therapies in Kidney Transplantationhu_HU
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