The management of skin manifestations in autoimmune diseases involves a combination of pharmacological and non-pharmacological therapies tailored to each patient. Pharmacological treatments include corticosteroids, immunosuppressants, and biologics, which target specific immune pathways to reduce inflammation and disease progression. Non-pharmacological approaches, such as phototherapy, dietary modifications, and lifestyle adjustments, play a supportive role in improving skin health and overall well-being. Understanding the mechanisms of action of various medications allows for a more precise selection of treatments, minimizing side effects while maximizing efficacy. By exploring these strategies, we can contribute to more personalized and effective treatment plans, ultimately improving outcomes for individuals with autoimmune skin conditions.