Intalesional therapies of melanoma

dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorVanessa, Nqumayo
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.date.accessioned2017-08-02T11:03:27Z
dc.date.available2017-08-02T11:03:27Z
dc.date.created2017-05-04
dc.description.abstractMalignant Melanoma is considered the most fatal skin tumor albeit it is of the least common malignancies. The intensification of studies on intralesional melanoma therapy directed at specific genetic modification of the herpes simplex virus 1, lead to the manufacturing of T-VEC, the first live virus to be used clinically as a therapeutic agent against malignant disease. Through deletion of HSV-1 gamma 34.5 and alpha 47 genes, this virus became effective. Clinically, the innovative action of T-VEC translates into three outstanding effects: improved durable and overall response rate, a decrease in tumor size and in some cases complete resolution. Overall, with its low toxicity profile and safety, T-VEC is able to offer a promising outcome for patients in late stage melanoma.hu_HU
dc.description.correctortben
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent36hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/242821
dc.language.isoenhu_HU
dc.subjectmelanomahu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleIntalesional therapies of melanomahu_HU
dc.title.subtitleTalimogene Laherparepvec (T-VEC)hu_HU
Fájlok