Synthesis of sugar-based (thio)semicarbazones as precursors of half-sandwich platinum-group metal complexes

Abstract

In the Chemical Glycobiology Research Group (Department of Organic Chemistry, University of Debrecen) many bioactive monosaccharide derivatives have been designed and synthesized for many years. During this work, sugar containing half-sandwich platinum-group metal complexes have been synthesized and patented. Some have shown (sub)micromolar cytostatic activity against carcinoma, lymphoma and sarcoma cancer. The aim of this research work was to synthesize sugar-based semicarbazone and thiosemicarbazone derivatives as percursors of new platinum-group metal complexes.