Adsorption of bovine serum albumin on silica aerogel surface: Detailed kinetic model of the system

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In this thesis, I investigated the interaction of bovine serum albumin (BSA) and mesoporous silica aerogel, which can be used as a potential drug carrier and tissue scaffold in the biomedical field. Since bovine serum albumin is similar to human serum albumin (HSA), it is suitable for modeling the aerogel-protein system.During the experiments, BSA adsorption was observed on the mesoporous silica surface, which was confirmed by light microscopic examinations. The obtained UV-vis kinetic data were corrected using the Dual-Wavelength Method of background correction, to eliminate the background caused by the turbidity of the aerogel suspension. The results suggest that a complex process occurs after the injection of BSA solution into the aerogel suspension.

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Kulcsszavak
Aerogel, sol-gel, BSA, adsorption, kinetic model, drug-delivery, zeta potential
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