Pain is the most problematic issue for patient therefore the use of painkiller or analgesia is widely use in dentistry. We are not only look at the effectiveness of the treatment, we also look at the implication of painkiller or analgesia, more specific Nonsteroidal anti-inflammatory agents, in dental use. The most often implication in dental practice with NSAIDs is GI alteration, kidney and cardiovascular complication, platelet aggregation, increase blood pressure and specially in pregnancy.