The purpose of this thesis is to give a holistic summary of ARNI use and its effects on noted cardiovascular and metabolic diseases. It aims to give background, pharmacology, and action of the drug in heart failure and hypertension. ARNI was found to be an effective pharmacotherapy in both heart failure and certain types of hypertension. It proved to be anti-hypertensive, anti-hypertrophic, and anti-fibrotic with the ability to reverse heart failure-associated remodeling and reduce morbidity and mortality associated with heart failure. It also significantly improved systolic blood pressure in general and elevated blood pressure in age-related hypertensive phenotypes.