Special Pharmacological Aspects of Kidney Diseases

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dc.contributor.advisorPórszász , Róbert
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorHafez, Emran
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzentmiklósi, József
dc.contributor.opponentHalasi, Barbara Dóra
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.date.accessioned2024-02-23T07:23:01Z
dc.date.available2024-02-23T07:23:01Z
dc.date.created2022-10-24
dc.description.abstractThe bean-shaped kidney has diverse important functions vital for life, which requires important treatments that may save this organ of any injuries. Amongst the kidney cancers, renal cell carcinoma is the most common, associated with VHL (Von Hippel- Lindau Disease), which is a tumor suppressor gene. Therapeutic approaches were focused on targeting factors that became overexpressed due to the loss of the VHL inhibitor function. The modern age came with useful anticancer treatments ranging from Sorafenib to Axitinib. For example, after a randomized progression free survival trial versus interferon alpha, Sunitinib demonstrated great beneficial effects. The pathology of inflammatory kidney disease involves various inflammatory mediators, and so using drugs to regulate the levels of inflammatory mediators such as TNF-alpha or Angiotensin II has become crucial. It can be done by targeting their receptors or nuclear factor-kappa B (NF-KB) expression. In nephrolithiasis, the stone composition varies, and therefore so does the treatment strategies. For example, if a patient shows hyperuricemia, we prescribe Allopurinol. In COVID-19 patients with renal injury a study was performed which shows how one group really benefitted more from combined Continuous renal replacement therapy (CRRT)/blood perfusion versus a group with blood perfusion treatment alone. The Pharmacological method to treating COVID-19 infection is a 2-phase approach. Additionally, there exists several antiviral therapies ranging from Chloroquine to Remdesivir and more. However, as with the case of treatments in other kidney diseases, there still requires further research and validity in these antiviral drugs.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent40
dc.identifier.urihttps://hdl.handle.net/2437/366797
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectKidney cancers, inflammatory kidney diseases, obstructive kidney diseases, COVID-19
dc.subject.dspaceMedicine::Pharmacology
dc.titleSpecial Pharmacological Aspects of Kidney Diseases
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