Protective effect of pomegranate fruit extracts against methotrexate-induced intestinal damage

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dc.contributor.advisorMegyeri, Attila
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorAbed Elmoati, Seraje
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2017-08-02T09:52:04Z
dc.date.available2017-08-02T09:52:04Z
dc.date.created2017-02-27
dc.description.abstractPomegranate (Punica granatum L.) is a long-lived and drought-tolerant plant. It is rich in bioactive components which has strong antioxidant, anti-inflammatory and anticancerous properties. Methotrexate (MTX) is an antifolate cytotoxic drug used to treat certain types of malignancies and several autoimmune diseases. MTX exerts its cytotoxic effects not only against cancer cells but also upon normal cells. Thus, a wide range of adverse reactions is inevitable; especially gastrointestinal side effects. Aims: This narrative review examines the existing literature in order to find out whether or not pomegranate is suitable to act against MTX induced mucosal damage.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent32hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/242798
dc.language.isoenhu_HU
dc.subjectpomegranate fruit extractshu_HU
dc.subjectintestinal mucositishu_HU
dc.subjectmethotrexatehu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titleProtective effect of pomegranate fruit extracts against methotrexate-induced intestinal damagehu_HU
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