In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity

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dc.contributor.authorNannini, Simon
dc.contributor.authorSieffert, Celine
dc.contributor.authorMcGown, Andrew
dc.contributor.authorGao, Xin-Yue
dc.contributor.authorJarvis, Amanda
dc.contributor.authorKostakis, George E.
dc.contributor.authorGalvácsi, Antal
dc.contributor.authorKállay, Csilla
dc.contributor.authorMoraru, Ruxandra
dc.contributor.authorBaud, Matthias G.
dc.contributor.authorMandel, Sebastian
dc.contributor.authorBalourdas, Dimitros-Ilias
dc.contributor.authorJoerger, Andreas C.
dc.contributor.authorOrvain, Christophe
dc.contributor.authorPeschard, Simon
dc.contributor.authorNion, Audrey
dc.contributor.authorMellitzer, Georg
dc.contributor.authorLottiaux, Sophie
dc.contributor.authorSpencer, John
dc.contributor.authorGross, Isabelle
dc.contributor.authorGaiddon, Christian
dc.date.accessioned2026-05-22T06:56:12Z
dc.date.available2026-05-22T06:56:12Z
dc.date.issued2026
dc.date.oa2026-05-22
dc.date.pasync2026-05-22T23:11:54Z
dc.date.updated2026-05-22T06:56:12Z
dc.description.correctorSZKM
dc.identifier.citationJournal Of Enzyme Inhibition And Medicinal Chemistry. -41 : 1 (2026). -J. Enzym. Inhib. Med. Chem. - 1475-6366
dc.identifier.doihttp://dx.doi.org/10.1080/14756366.2026.2638836
dc.identifier.issn1475-6366
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM137536
dc.identifier.urihttps://hdl.handle.net/2437/407299
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/14756366.2026.2638836
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerSzerző
dc.subject.mabTermészettudományok
dc.subject.mabKémiai tudományok
dc.titleIn vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity
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