Pharmacological aspect in treating Tourette syndrome

Abstract

Tourette's syndrome is a developmental neuropsychiatric disorder characterized by multiple, brief, recurrent, nonrhythmic movements and one or more vocalizations called tics. Management of TS includes: pharmacological agents, behavioral therapy, psychoeducation and deep brain stimulation. The evidence for efficacy of the pharmacological agents used in treatment of TS is often based on open studies or randomized, double-blind, placebo-controlled studies with quite small sample sizes. Hence, there exists only one drug which has been approved for TS widely in Europe, which is haloperidol. However, because of its adverse reactions it is nowadays usually a drug of third line in clinical practice.