Effect of long-term consumption of carotenoid enriched corn on chemosensitivity of rat granulocyte–macrophage progenitor cells

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dc.contributor.advisorMegyeri, Attila
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorMori, Kenryo
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2026-04-14T07:07:55Z
dc.date.available2026-04-14T07:07:55Z
dc.date.created2026-04-07
dc.description.abstractThis essay investigates whether long-term dietary consumption of lutein- and zeaxanthin-enriched corn affects the chemosensitivity of rat hematopoietic progenitor cells to doxorubicin. Using a CFU-GM colony-forming assay, dose–response relationships were analyzed after prolonged feeding, revealing that doxorubicin reduced colony formation in all groups in a concentration-dependent manner. While individual supplementation with lutein or zeaxanthin showed a trend toward decreased chemosensitivity (higher IC50 values), combined supplementation unexpectedly increased sensitivity, as reflected by a lower IC50. These findings suggest that carotenoids may modulate hematopoietic responses to cytotoxic stress, potentially through antioxidant and membrane-related mechanisms. However, substantial variability and small sample sizes limit definitive conclusions regarding their protective effects. Overall, this study highlights the complex and context-dependent interaction between dietary antioxidants and chemotherapy-induced toxicity, warranting further investigation.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent28
dc.identifier.urihttps://hdl.handle.net/2437/406182
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectLutein
dc.subjectZeaxanthin
dc.subjectCarotenoids
dc.subjectDoxorubicin
dc.subjectChemosensitivity
dc.subjectMyelosuppression
dc.subjectHematopoietic progenitor cells
dc.subjectCFU-GM assay
dc.subjectOxidative stress
dc.subjectAntioxidant supplementation
dc.subject.dspaceMedicine::Pharmacology
dc.titleEffect of long-term consumption of carotenoid enriched corn on chemosensitivity of rat granulocyte–macrophage progenitor cells
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