Treatment of Relapsing Forms of Multiple Sclerosis

Abstract

This thesis explores the treatment of relapsing forms of multiple sclerosis (MS), an autoimmune disorder that causes demyelination, axonal damage, and neurodegeneration due to immune-mediated attacks on oligodendrocyte-derived myelin. It begins with an overview of MS types, clinical symptoms, and diagnostic approaches, followed by an in-depth examination of its pathophysiology, emphasizing the roles of T cells, B cells, and immunological tolerance in disease progression. The work reviews current treatments, including immunomodulatory agents and disease-modifying therapies delivered via injection, infusion, or oral administration, as well as options for managing acute relapses such as corticosteroids and plasmapheresis.