Significance of Germline mutations in Pediatric Acute Lymphoblastic leukemia

Abstract

The primary aim of this thesis is to thoroughly describe the genetics of Pediatric Acute Lymphoblastic leukemia (pALL) , highlight existing literature on germline mutations, investigate and map the current research on the importance of germline mutations in pediatric ALL. The thesis will also give a thorough and systematic summary of the present state of knowledge, identifying significant themes, patterns, and gaps in research on Pediatric ALL.