Use of Histone Deacetylase Inhibitors (HDIs): Novel Advances in Cancer Treatment

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDepartment of Pharmacology and Pharmacotherapyhu_HU
dc.contributor.authorZavoshi, Shirin
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.date.accessioned2019-09-26T11:41:04Z
dc.date.available2019-09-26T11:41:04Z
dc.date.created2019-04-24
dc.description.abstractEpigenetic regulations result in variations in gene expression that do not modify the DNA sequence directly but rather impact gene expression through covalent modification of DNA or other associated proteins involved. Multiple disease conditions are related to epigenetic changes and due to this it is critical to better understand this phenomenon in order to develop novel therapeutic measures in all the related fields of interest. The actions of HATs and HDACs are the center of studies in regard to epigenetic modulations. Cancer progression is driven by the incremental buildup of genetic mutations as well as the dysfunction of the epigenetic modulatory mechanisms and these factors along with others contribute to the development of malignancy. Investigating the detailed mechanism of epigenetic regulation in cancer initiation and progression will help us better comprehend the pathogenesis of cancer and also allows us to discover more efficient therapeutic targets and medications for cancer treatment.hu_HU
dc.description.correctorLB
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent34hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/273784
dc.language.isoenhu_HU
dc.subjectHistone Deacetylase Inhibitors (HDIs)hu_HU
dc.subjectNovel Cancer Treatmenthu_HU
dc.subjectEpigenetic Principlehu_HU
dc.subject.dspaceMedicinehu_HU
dc.titleUse of Histone Deacetylase Inhibitors (HDIs): Novel Advances in Cancer Treatmenthu_HU
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