Synthesis and Characterization of 6-Bromo-Benzoflavanone Derivatives

A tétel rövid nézete
dc.contributor.advisorKónya, Krisztina
dc.contributor.authorAmin, Yasmin
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézet
dc.date.accessioned2024-12-18T07:33:50Z
dc.date.available2024-12-18T07:33:50Z
dc.date.created2024-11-14
dc.description.abstractThis thesis presents the development of an efficient synthesis pathway for 6-bromo-benzoflavanone as aromatase inhibition for cancer treatment, aiming to optimize yield and enhance stereoselectivity. The process begins with the bromination of 1-(1-hydroxynaphthalen-2-yl)ethan-1-one, followed by protection of the hydroxyl group, and Claisen-Schmidt condensation to form chalcone derivatives with variable yields. Microwave-assisted cyclization using trifluoroacetic acid was employed after unsuccessful attempts with other cyclization methods, resulting in a 28% yield of the target flavanone compound. Then the 6-bromo-benzoflavanone is utilized as a reference compound in rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to chromenones, yielding high enantioselectivities, and its structure was confirmed through NMR.
dc.description.courseBiochemical engineering
dc.description.degreeBSc/BA
dc.format.extent29
dc.identifier.urihttps://hdl.handle.net/2437/383832
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectFlavonoids
dc.subjectMicrowave-Assisted Synthesis
dc.subjectEnantioselective Synthesis
dc.subjectClaisen-Schmidt condensation
dc.subjectCyclization
dc.subjectAromatase Inhibition
dc.subject.dspaceChemistry
dc.titleSynthesis and Characterization of 6-Bromo-Benzoflavanone Derivatives
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
Yasmina thesis 11.12 without statement.pdf
Méret:
1.38 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Science and Technology)