In Vitro Susceptibility of C. albicans C. krusei and C. parapsilosis to Amb and ASZ-07 and FAND-17

Abstract

The main purpose of this study was to investigate the possible antifungal activity of agents called FAND-17 which is an intermediate product of L-iduronic acid synthesis and ASZ-07 which is an intermediate product during 6-deoxy-L-talose containing pentasaccharides production on three different Candida species. In this study, we used well known antifungal agent called Amphotericin B with ASZ-07 and FAND-17 on three different Candida species: Candida albicans, Candida krusei, and Candida parapsilosis. ASZ-07 and FAND-17 showed no significant inhibitory effect on all 3 samples. This is one of the first studies that investigate the possible antifungal effects of ASZ-07 and FAND-17 on Candida species. While AmB had different minimum inhibition concentrations on the 3 Candida species.