The Surgical and Biological Therapy of Basal Cell Carcinoma

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorFink, Benjamin Emile
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.date.accessioned2020-10-15T08:57:57Z
dc.date.available2020-10-15T08:57:57Z
dc.date.created2020
dc.description.abstractBasal Cell Cancer (BCC) is the most common cancer in the world, affecting an estimated 2 million Americans annually. The Incidence of BCC is rising exponentially, with the percentage rise in incidence at 8% in 2006 going up every year. Historically, surgery and cautery were the only treatment options available. Contemporary treatments of straightforward BCC lesions still revolve around these two principles. However, they are more refined; incorporating histopathological analysis and modern surgical techniques allowing us to achieve better cosmetic and functional results. Recent developments in Genomics and the discovery in the role of the Sonic hedgehog (SHh) pathway in the pathomechanism of BCC, has allowed for the invention of Vismodogib; a first-in-class biological therapy inhibiting this pathway, allowing us to treat more complex BCC cases that were until recently dealt with palitively. The purpose of this work is to explain the treatment options available in the management of BCC and their context.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent34 pageshu_HU
dc.identifier.urihttp://hdl.handle.net/2437/296760
dc.language.isoenhu_HU
dc.subjectVismodegibhu_HU
dc.subjectBCChu_HU
dc.subjectBasal Cell Cancerhu_HU
dc.subjectBasal Cell Carcinomahu_HU
dc.subjectSkin Cancerhu_HU
dc.subjectBiological Therapyhu_HU
dc.subjectSurgeryhu_HU
dc.subjectMohs Micrographic Surgeryhu_HU
dc.subjectPlastic Surgeryhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleThe Surgical and Biological Therapy of Basal Cell Carcinomahu_HU
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