The Role of Solute Carrier Transporters in Brown Adipocytes

A tétel rövid nézete
dc.contributor.advisorKristóf, Endre Károly
dc.contributor.authorSucipto, Abby Kurniawati
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézet
dc.date.accessioned2023-05-02T06:45:30Z
dc.date.available2023-05-02T06:45:30Z
dc.date.created2023-04-28
dc.description.abstractAdipose tissues, including white adipose tissue (WAT) and brown adipose tissue (BAT), play a critical role in regulating insulin sensitivity and energy homeostasis, making them potential targets for clinical interventions to fight against obesity. BAT utilize excess nutrients to generate heat through various mechanisms, including the presence of UCP1, which allows proton leak in the mitochondrial matrix, and the use of branched-chain amino acids (BCAAs) as fuel for thermogenesis. This process simultaenously clears excess serum BCAAs, which can cause insulin resistance, type 2 diabetes, and obesity. Solute carrier (SLC) transporters, such as FATP1, ASC-1, and ThTr2, support and regulate the thermogenic activity of BAT by mediating the uptake of fatty acids, small neutral amino acids, and thiamine, respecctively. These transporters play a significant role in supporting various metabolic pathways and maintaining high thermogenic activity in BAT.
dc.description.correctorLB
dc.description.courseBiology
dc.description.degreeBSc/BA
dc.format.extent23
dc.identifier.urihttps://hdl.handle.net/2437/351370
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectBrown Adipocytes
dc.subjectSolute Carrier Transporters (SLC)
dc.subjectNon-shivering thermogenesis
dc.subjectObesity
dc.subjectUCP1
dc.subject.dspaceDEENK Témalista::Biológiai tudományok
dc.titleThe Role of Solute Carrier Transporters in Brown Adipocytes
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