Histological evaluation of PD-L1 antibody in Head and Neck Squamous Cell Carcinomas (HNSCC)

A tétel rövid nézete
dc.contributor.advisorCsonka, Tamás
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Pathológiai Intézet
dc.contributor.authorPicanco Silva, Yasmin
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentAnna Orsolya
dc.contributor.opponentdeptÁltalános Orvostudományi Kar
dc.date.accessioned2024-08-21T07:13:48Z
dc.date.available2024-08-21T07:13:48Z
dc.date.created2023-11-09
dc.description.abstractThe thesis delves into the critical role of programmed death-ligand 1 (PD-L1) in Head and Neck Squamous Cell Carcinoma (HNSCC). PD-L1, a transmembrane protein found in tumor cells and immune cells, is expressed in higher amounts in specific cancer types, aiding tumors in evading the immune system. The study investigates the use of PD-L1 expression as a predictor of tumor aggressiveness and the efficacy of PD-L1/PD-1 blockers in immunotherapy, notably KEYTRUDA® (Pembrolizumab) and TECENTRIQ® (Atezolizumab). Through meticulous analysis of biopsy samples from HNSCC patients, the research compares the performance of two different PD-L1 immunohistochemistry assays: PD-L1 IHC 22C3 PharmDx Assay by Agilent and VENTANA PD-L1 (SP142) Assay by Roche. Despite technical limitations, the study effectively demonstrates a higher detection of PD-L1 expression in HNSCC tissue samples using the PD-L1 IHC 22C3 PharmDx Assay by Agilent compared to the VENTANA PD-L1 (SP142) Assay by Roche. This research underscores the significance of histological evaluation of PD-L1 antibodies as a valuable tool in guiding immunotherapy treatment decisions for HNSCC patients, offering practical insights for clinical practice.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent38
dc.identifier.urihttps://hdl.handle.net/2437/379117
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectHistology, HNSCC, PD-L1
dc.subject.dspaceMedicine::Molecular Pathology
dc.titleHistological evaluation of PD-L1 antibody in Head and Neck Squamous Cell Carcinomas (HNSCC)
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
YasminSilva_Thesis_pdf.edCsT.v2.pdf
Méret:
17.11 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Medicine)