SUBLINEAGE-SPECIFIC A45S POLYMORPHISM ALTERS THE BIOLOGICAL FUNCTION OF THE HUMAN PAPILLOMAVIRUS 11 E7 ONCOPROTEIN

A tétel rövid nézete
dc.contributor.advisorSzalmás, Anita
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Orvosi Mikrobiológiai Intézet
dc.contributor.authorDagane, Abdinoor
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.date.accessioned2026-06-11T16:52:38Z
dc.date.available2026-06-11T16:52:38Z
dc.date.created2026-06-05
dc.description.abstractThis thesis investigates how a naturally occurring A45S amino acid substitution in the HPV11 E7 oncoprotein affects its biological function and potential role in disease progression. The study found that the HPV11 A2 (S45) variant more effectively degrades pRb family proteins, leading to enhanced activation of E2F-regulated genes compared to the prototype HPV11 A1 variant. Increased expression of DNA repair genes, including BRCA1, BRCA2, RAD51, and ATM, was observed in keratinocytes expressing the S45 variant, suggesting stronger modulation of host cellular pathways. Additionally, cells expressing HPV11 S45 E7 exhibited reduced cytotoxicity and improved viability, indicating a greater capacity to support viral persistence. Overall, the findings suggest that the A45S polymorphism gives HPV11 E7 high-risk-like molecular properties that may contribute to the aggressiveness and persistence of HPV11-associated diseases such as recurrent respiratory papillomatosis.
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecImmunológia, sejt- és mikrobiológia
dc.description.degreeMSc/MA
dc.format.extent33
dc.identifier.urihttps://hdl.handle.net/2437/409420
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectHuman Papillomavirus, E7, E2F, Retinoblastoma
dc.subject.dspaceMedicine::Medical microbiology
dc.subject.dspaceBiology::Molecular Biology
dc.titleSUBLINEAGE-SPECIFIC A45S POLYMORPHISM ALTERS THE BIOLOGICAL FUNCTION OF THE HUMAN PAPILLOMAVIRUS 11 E7 ONCOPROTEIN
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
Thesis Essay 2026.pdf
Méret:
1.04 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Medicine)