Serotonergic phsychedelics in PTSD: Mechanisms of neuroplasticity and pharmacological action
| dc.contributor.advisor | Varga, Balázs | |
| dc.contributor.advisordept | Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
| dc.contributor.author | Zaman, Anta Ariana | |
| dc.contributor.department | DE--Általános Orvostudományi Kar | |
| dc.contributor.opponent | Lekli, István | |
| dc.contributor.opponent | Bombicz, Mariann | |
| dc.contributor.opponentdept | Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék | |
| dc.contributor.opponentdept | Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
| dc.date.accessioned | 2025-11-13T08:14:25Z | |
| dc.date.available | 2025-11-13T08:14:25Z | |
| dc.date.created | 2025-11-10 | |
| dc.description.abstract | This thesis explores the pharmacological mechanisms of serotonergic psychedelics, primarily psilocybin and MDMA, in relation to neuroplasticity and their potential to treat post-traumatic stress disorder (PTSD). It reviews neurobiological pathways, including 5-HT2A receptor stimulation and brain-derived neurotrophic factor (BDNF) up-regulation, supporting synaptic growth and fear extinction. The thesis compares these psychedelics with ketamine and highlights clinical trial outcomes showing promising symptom reduction with psychedelic-assisted psychotherapy. Ethical, regulatory, and safety considerations for clinical use are discussed, emphasising the need for trauma-informed therapeutic protocols. The work underscores neuroplasticity as a key therapeutic target while calling for further PTSD-specific clinical research to establish treatment durability. | |
| dc.description.course | általános orvos | |
| dc.description.courselang | angol | |
| dc.description.degree | egységes, osztatlan | |
| dc.format.extent | 36 | |
| dc.identifier.uri | https://hdl.handle.net/2437/398701 | |
| dc.language.iso | en | |
| dc.rights.info | Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében. | |
| dc.subject | Serotenergic Psychedelics | |
| dc.subject | PTSD | |
| dc.subject | Neuroplasticity | |
| dc.subject.dspace | Medicine::Pharmacology | |
| dc.title | Serotonergic phsychedelics in PTSD: Mechanisms of neuroplasticity and pharmacological action | |
| dc.title.translated | Serotenergic Psychedelics in PTSD: Mechanisms of Neuroplasticity and Pharmocological Action |
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