Developmental defects of the enamel are disturbances of the dental hard tissue caused by many etiological factors, including the use of certain drugs. These can lead to complaints of increased sensitivity and esthetic issues. Disturbances to the process of amelogenesis during its different stages produce different types of enamel defects. Drugs including Anti-epileptic drugs, antibiotics, fluoride, chemotherapeutic agents, asthma medications and NSAIDs are commonly prescribed to pregnant women and young children. All drugs except for antibiotics and asthma medications showed an exclusive relationship between their use and the development of enamel defects.