Pharmacological Basis of Melanoma Chemotherapy

dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorIto, Midori
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2022-08-29T07:55:05Z
dc.date.available2022-08-29T07:55:05Z
dc.date.created2022-05-18
dc.description.abstractMelanoma is the most aggressive and lethal type of skin cancer. First-line therapy for metastatic melanoma is either immune checkpoint inhibitors or BRAF/MEK inhibitors, however, chemotherapy plays an important role in palliative treatment of refractory melanoma. Three classes of cytotoxic chemotherapy, alkylating agents (dacarbazine, temozolomide, nitrosoureas), platinum drugs (cisplatin, carboplatin), and plant alkaloids (paclitaxel, nab-paclitaxel, docetaxel) have been investigated in clinical trials as monotherapy or combination therapy. Pharmacological basis of these drugs is gone into detail in this thesis. Also, the development of resistance to each drug is summarized since melanoma is generally resistant to chemotherapy.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent39hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336812
dc.language.isoenhu_HU
dc.subjectMelanomahu_HU
dc.subjectChemotherapyhu_HU
dc.subjectPharmacologyhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titlePharmacological Basis of Melanoma Chemotherapyhu_HU
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