Pharmacological Therapy of Glaucoma with Special Focus on Monoclonal Antibodies

dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorSigalov, Ron
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentHalasi, Barbara
dc.contributor.opponentSzentmiklósi, József
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.date.accessioned2025-05-14T13:35:01Z
dc.date.available2025-05-14T13:35:01Z
dc.date.created2025-05-09
dc.description.abstractGlaucoma is a complex and progressive optic neuropathy characterized by retinal ganglion cell (RGC) degeneration and optic nerve damage, ultimately leading to irreversible vision loss. While elevated intraocular pressure (IOP) is the primary modifiable risk factor, disease progression often occurs even with effective IOP control, highlighting the need for alternative therapeutic strategies. This thesis explores current theories of glaucoma pathogenesis, with a focus on immunological dysregulation, neuroinflammation, and vascular abnormalities. Particular attention is given to monoclonal antibodies (mAbs) as emerging tools in targeted pharmacological therapy, with the potential to offer neuroprotection and disease modification. In addition, the work reviews innovative treatment strategies and advanced drug delivery systems that aim to go beyond symptom management and address the underlying causes of glaucoma. By integrating immunological, pharmacological, and biotechnological perspectives, the thesis supports the potential of mechanism-driven therapies to reshape glaucoma treatment and improve long-term visual outcomes.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent50
dc.identifier.urihttps://hdl.handle.net/2437/389916
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectGlaucoma
dc.subjectMonoclonal Antibodies
dc.subjectNeuroprotection
dc.subject.dspaceMedicine::Pharmacology
dc.titlePharmacological Therapy of Glaucoma with Special Focus on Monoclonal Antibodies
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