Treatment of Levodopa induced motor complications with continuous Levodopa/Carbidopa in Parkinson's disease

A tétel rövid nézete
dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorAdam Dagan, Shaked
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentHalasi, Barbara Dóra
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.date.accessioned2023-07-20T08:46:55Z
dc.date.available2023-07-20T08:46:55Z
dc.date.created2023-05-08
dc.description.abstractParkinson's disease is a neurodegenerative disorder characterized by the degenerationdopamine-producingcing neurons. The gold standard therfory of the diseasethe is administration of levodopa/cawhichopa that aims to replenish the missing dopamine in the brain of patients. When orally taken levodopa causes pulsatile no physiologic stimulation of dopaminergic neurons in the brain, which is believed to be the cause of the appearalevodopa-inducedinduced motor complications such as on-off fluctuations and dyskinesias. It is believed that continuous levodopa administration that will mimic a more physiological stimulation is the key to decreasing these motor complications. The available medications that provide continuous levodopa administration are levodopa intestinal gel infusion (Duodopa,) , ND0612 and Rytary (IPX066) that already show improvement in the motor complications of prolonged levodopa use in patients with Parkinson's disease.
dc.description.correctorLB
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.coursespecOrvosbiológia-farmakológia
dc.description.degreeegységes, osztatlan
dc.format.extent35
dc.identifier.urihttps://hdl.handle.net/2437/357722
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectParkinsons disease
dc.subjectLevodopa-carbidopa
dc.subjectcontinous Levodopa administration
dc.subjectlevodopa induced motor complications
dc.subjectlevodopa induced dyskinesia
dc.subjectND0612
dc.subjectLevodopa intestinal gel infusion
dc.subjectRytary (IPX066)
dc.subject.dspaceDEENK Témalista::Orvostudomány
dc.titleTreatment of Levodopa induced motor complications with continuous Levodopa/Carbidopa in Parkinson's disease
Fájlok
Gyűjtemények
Theses (Faculty of Medicine)