Antitumor Effects of Cannabinoid Derivatives on Breast Cancer Cell Lines

A tétel rövid nézete
dc.contributor.advisorDobos, Nikoletta
dc.contributor.advisordeptGyógyszerésztudományi Kar
dc.contributor.authorChukwudi , Ojelubechukwu
dc.contributor.departmentDE--Gyógyszerésztudományi Kar
dc.contributor.opponentLekli, Istvan
dc.contributor.opponentdeptGyógyszerésztudományi Kar
dc.date.accessioned2025-04-14T07:36:18Z
dc.date.available2025-04-14T07:36:18Z
dc.date.created2025-04-12
dc.description.abstractThe thesis "Antitumor Effects of Cannabinoid Derivatives on Breast Cancer Cell Lines" written by Chukwudi Ojelubechukwu Chioma investigates the antitumor effects of newly synthesized cannabinoid derivatives on breast cancer cell lines. The experimental work focuses on two types of cell lines: MDA-MB-231 (triple-negative breast cancer cell line) and MCF-7 (hormone-receptor positive breast cancer cell line), assessing cytotoxicity of twelve CBD (Cannabidiol) and CBG (Cannabigerol) derivatives. These compounds were synthesized via a Mannich-type reaction and tested using the MTT cell viability assay at different concentrations and time points. Results revealed that CBD derivatives like PFD43I and PFD10/AI were particularly effective against MDA-MB-231, while PFD45I (CBG) and PFD11/A (CBD) had strong effects in reducing the MCF-7 cell viability. The six most potent compounds underwent further IC50 testing, which showed that CBG derivatives had the best effect overall. The findings support further investigation into these compounds as potential breast cancer therapies, with future research aimed at a deeper exploration into their molecular mechanisms.
dc.description.coursegyógyszerész
dc.description.courselangangol
dc.description.coursespecOrvosbiológia-farmakológia
dc.description.degreeBSc/BA
dc.format.extent46
dc.identifier.urihttps://hdl.handle.net/2437/389051
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectBreast Cancer
dc.subjectCannabinoids
dc.subjectAntitumor Activity
dc.subject.dspaceChemistry
dc.subject.dspaceBiology
dc.subject.dspaceMedicine
dc.titleAntitumor Effects of Cannabinoid Derivatives on Breast Cancer Cell Lines
dc.title.subtitleAntitumor Effects of Cannabinoid Derivatives on Breast Cancer Cell Lines
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