Synthesis and characterization of a Mn(II)-based Magnetic Resonance Imaging(MRI) contrast agent candidate derived from pyclen

Abstract

MRI is one of the best-known and most widely used imaging techniques in modern medicine, and its popularity is due to its non-invasive and non-destructive features. Since the 1980s, Gd(III)-based contrast agents have been market leaders, but in recent years, confidence has been shaken by the toxicity of the released gadolinium(III) ions. The essential nature of metal ions is applied to replace Gd(III)-ions in most cases (represented by Mn2+). For manganese complexation, the ligand O2PC6OX was designed and synthesized, and its Mn(II) complex was investigated in order to evaluate its thermodynamic, kinetic, and relaxometric features, with the goal of obtaining a Mn(II) complex with improved physico-chemical parameters.