This is a literature review thesis about the emerging tau-targeted approaches in the treatment of Alzheimer's disease. Currently available conventional therapy only brings the symptomatic relief to the patients. However, the emerging tau-targeted approaches are focused due to its disease modifying potentials. Tau-targeted therapy can be divided into 3 categories, enzyme targeted therapy, tau aggregation therapy, and immunotherapy. this review also describes the limitation in the clinical translation of those approaches from experimental reserach.