Synthetic control devices for Penicillium chrysogenum

A tétel rövid nézete
dc.contributor.advisorNygård, Yvonne
dc.contributor.advisorKaraffa, Levente
dc.contributor.authorMózsik, László
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézethu_HU
dc.date.accessioned2016-05-05T13:15:28Z
dc.date.available2016-05-05T13:15:28Z
dc.date.created2016
dc.description.abstractThe filamentous fungus Penicillium chrysogenum is the major producer of the beta-lactam antibiotic penicillin. In addition to the penicillin biosynthesis cluster, the genome of P. chrysogenum contains a large number of uncharacterized secondary metabolite gene clusters. However, many of these clusters are not expressed under laboratory conditions. This thesis summarizes the steps of developing a novel, orthogonal, synthetic transcriptional regulation system in P. chrysogenum. The system utilizes transcriptional regulatory genes to express the gene of interests with a strong but controllable manner. The build system can be used for heterologous expression or silenced genes, even whole gene clusters can be activated with it.hu_HU
dc.description.correctorgj
dc.description.courseBiomérnöki MSchu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent54hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/226524
dc.language.isoenhu_HU
dc.subjectheterologous expressionhu_HU
dc.subjectsynthetic biologyhu_HU
dc.subjectreporter expressionhu_HU
dc.subjectgene regulationhu_HU
dc.subjecttranscriptional factorhu_HU
dc.subjectsilent gene cluster activationhu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományokhu_HU
dc.titleSynthetic control devices for Penicillium chrysogenumhu_HU
dc.title.subtitleA genetic tool for transcriptional regulation in Penicillium chrysogenumhu_HU
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Hallgatói dolgozatok (Természettudományi és Technológiai Kar)