Pharmacological aspects of antituberculous drugs

Abstract

Tuberculosis disease is a life-threatening disease, the second most common infectious disease leading to death worldwide after HIV. An early diagnosis and treatment of active tuberculosis disease and LTBI, is important to prevent the spreading of the bacteria and protection of the individual health. First-line antituberculous drugs rifampin, isoniazid, ethambutol and pyrazinamide are highly effective against tuberculosis, given for 6 months period. Patient should persist in taking the drug daily without interruption, because therapy interruption can lead to development of drugs resistant tuberculosis strains, which would be harder to treat.