My thesis focuses on formulation and investigation of BGP-15 Containing topical gel.BGP-15 ,a compound known for its cytoprotective and anti-inflammatory properties. The primary objective was to create a stable,effectIve gel formulation using gelling agent such as HPMC.Extensive physicochemical characterisation was performed, including pH measurement , texture analysis and in vitro drug release studies. The results demonstrated that the optimized gel formulation provided desirable properties for topical application and maintained the stability and release of BGP-15 effectively. Overall,the study supports the potential use of BGP-15 in dermatological therapies through gel-based delivery systems.