Pharmacological management of migraine

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorKwon, Yesul
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.date.accessioned2020-02-24T09:16:20Z
dc.date.available2020-02-24T09:16:20Z
dc.date.created2019-05-22
dc.description.abstractMigraine is one of the most common, disabling neurological disorder characterized by multiple phases: premonitory, aura, and headache. Understanding of the pathophysiology of each phase of migraine has developed over recent years. First, the premonitory phase begins early around 3 days before the headache phase, and involves in the complex interaction between various cortical and subcortical brain regions, including the hypothalamus and brainstem nuclei that regulate nociceptive signaling. The third phase, headache phase involves activation of the trigeminovascular system, the mechanism that is well characterized. In one third of patients, during attacks aura phase may occur and likely correlates with a cortical spreading depression-like events, slowly propagating waves of the neuronal and glial cell depolarization and hyperpolarization. The characteristic at each pathophysiological stage of the migraine is improved, and it will give the identification of new therapeutic targets for the migraine prevention. This review includes the clinical features and neurobiology of migraine and available biological therapies are discussed.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent43hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/281123
dc.language.isoenhu_HU
dc.subjectMigrainehu_HU
dc.subjectCGRPhu_HU
dc.subjectTriptanhu_HU
dc.subjectpharmacological treatmenthu_HU
dc.subjectaurahu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titlePharmacological management of migrainehu_HU
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