Reduced Relaxation Response to Nitroglycerin of the Gallbladder Relative to the Sphincter of Oddi in Rabbits

A tétel rövid nézete
dc.contributor.advisorSzilvássy, Zoltán
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorVitézy, Botond
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2021-06-18T10:54:53Z
dc.date.available2021-06-18T10:54:53Z
dc.date.created2019
dc.description.abstractOrganic nitrates confer relief on Sphincter of Oddi spasm but they produce a weak relaxant effect on the gallbladder. We studied whether this is explained by a different biodegradation of nitroglycerin to nitric oxide (NO) in rabbits. Sodium nitroprusside induced relaxation of the SO is similar to that of the GB, while the relaxing effect of nitroglycerin was more prominent in the SO than in the GB. No difference in the relaxation response was seen to nitroglycerin and SNP in both tissues when they were mounted together with aortic rings. Neither baseline NO nor cGMP content increased in response to nitroglycerin, but both increased in the SO. Immunohistochemistry revealed the presence of NOS in SO and its absence in GB. Dissimilarity in nitroglycerin responsiveness of SO and GB is explained by a variance in nitroglycerin-biodegradation to NO.hu_HU
dc.description.correctorLB
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent25hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/311362
dc.language.isoenhu_HU
dc.subjectnitroglycerinhu_HU
dc.subjectgall bladderhu_HU
dc.subjectsphincter of oddihu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleReduced Relaxation Response to Nitroglycerin of the Gallbladder Relative to the Sphincter of Oddi in Rabbitshu_HU
Fájlok
Gyűjtemények
Theses (Faculty of Medicine)