Use of histone deacetylase inhibitors: Novel advances in cancer treatment
| dc.contributor.advisor | Pórszász, Róbert | |
| dc.contributor.advisordept | Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | hu_HU |
| dc.contributor.author | Dogantimur, Ozge | |
| dc.contributor.department | DE--Általános Orvostudományi Kar | hu_HU |
| dc.contributor.opponent | Szentmiklósi, József András | |
| dc.contributor.opponent | Drimba, László | |
| dc.contributor.opponentdept | Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | hu_HU |
| dc.contributor.opponentdept | Kenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztály | hu_HU |
| dc.date.accessioned | 2020-02-26T11:58:11Z | |
| dc.date.available | 2020-02-26T11:58:11Z | |
| dc.date.created | 2020-01-15 | |
| dc.description.abstract | Histone deacetylase inhibitors (HDACIs) are a reassuring group of anti-cancer drugs that alters the gene expression patterns of cancer cells through epigenetic modulation. HDACIs have been reported to intercede with mechanisms along with cell cycle arrest, differentiation, autophagy and apoptosis. They have a vital role in the regulation of tumor cell proliferation. HDACIs have been shown to terminate cell cycle progression at G1 and G2-M phases, reduce chromatin and might also prevent angiogenesis. They have been accepted primarily for use in cutaneous T-cell lymphoma, peripheral T-cell lymphoma, multiple myeloma, acute myeloid leukemia, myelodysplastic syndrome and non-Hodgkin lymphoma. | hu_HU |
| dc.description.course | általános orvos | hu_HU |
| dc.description.courselang | angol | hu_HU |
| dc.description.degree | egységes, osztatlan | hu_HU |
| dc.format.extent | 34 | hu_HU |
| dc.identifier.uri | http://hdl.handle.net/2437/281256 | |
| dc.language.iso | en | hu_HU |
| dc.subject | histone modifications | hu_HU |
| dc.subject | cancer epigenetics | |
| dc.subject | histone deacetylase inhibitors | |
| dc.subject.dspace | DEENK Témalista::Orvostudomány::Farmakológia | hu_HU |
| dc.title | Use of histone deacetylase inhibitors: Novel advances in cancer treatment | hu_HU |