Use of histone deacetylase inhibitors: Novel advances in cancer treatment

dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorDogantimur, Ozge
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.date.accessioned2020-02-26T11:58:11Z
dc.date.available2020-02-26T11:58:11Z
dc.date.created2020-01-15
dc.description.abstractHistone deacetylase inhibitors (HDACIs) are a reassuring group of anti-cancer drugs that alters the gene expression patterns of cancer cells through epigenetic modulation. HDACIs have been reported to intercede with mechanisms along with cell cycle arrest, differentiation, autophagy and apoptosis. They have a vital role in the regulation of tumor cell proliferation. HDACIs have been shown to terminate cell cycle progression at G1 and G2-M phases, reduce chromatin and might also prevent angiogenesis. They have been accepted primarily for use in cutaneous T-cell lymphoma, peripheral T-cell lymphoma, multiple myeloma, acute myeloid leukemia, myelodysplastic syndrome and non-Hodgkin lymphoma.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent34hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/281256
dc.language.isoenhu_HU
dc.subjecthistone modificationshu_HU
dc.subjectcancer epigenetics
dc.subjecthistone deacetylase inhibitors
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titleUse of histone deacetylase inhibitors: Novel advances in cancer treatmenthu_HU
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