Biological Effects of Newly Synthesized CBD and CBG Derivatives on Colon Cancer Cell Lines

Abstract

The aim of the theses is to examine the biological effects of newly synthesized cannabinoids derivatives on colon cancer cell lines. Cannabidiol is a nonpsychoactive phytocannabinoid that can be found in Cannabis sativa and it possesses numerous pharmacological effects. The therapeutic potential of the CBD and CBG have been investigated in numerous clinical trials for the treatment of various types of cancer. Here the ILKA675 and ILKA676 which are the newly synthesized derivatives of CBD and CBG are examined to assess the cytotoxic and antioxidant effect on HCT116 colon cancer cell lines. The biological assay used in the theses are MTT ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) assay and FRAP (Ferric Reducing Antioxidant Power) assay.