Szerző szerinti böngészés "Aftab Khan, Ruqayya"
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Tétel Korlátozottan hozzáférhető Study of miRNAs as biomarker in lung Adenocarcinoma associated brain tumorAftab Khan, Ruqayya; Hádáné Birkó, Zsuzsanna; Torner, Bernadett; Általános Orvostudományi Kar::Humángenetikai Tanszék; DE--Általános Orvostudományi KarWe aimed to compare the miRNA expression pattern in malignant tissue samples with lung adenocarcinoma-associated brain tumors and control brain tissue samples from healthy individuals, to develop a miRNA panel that can help reliably distinguish between tumor and healthy samples, potentially serving as biomarkers for adenocarcinoma-associated brain tumors. Two miRNAs, hsa-miR-200c-5p and hsa-miR-141-5p, were identified as significantly upregulated in adenocarcinoma associated brain tumor samples compared to control samples. The identification of hsa-miR-200c-5p and hsa-miR-141-5p as potential biomarkers for lung adenocarcinoma-associated brain tumors opens avenues for early diagnosis of metastatic brain tumors from lung adenocarcinoma and to distinguish it from other brain tumors.