Study of miRNAs as biomarker in lung Adenocarcinoma associated brain tumor

Fájlok
DECLARATION I, the undersigned Ruqayya Aftab Khan, a student of the University of Debrecen, Faculty of Medicine, being fully aware of my legal liability, do thereby declare and certify with my signature that my thesis, entitled Study of miRNAs as biomarker in lung Adenocarcinoma associated brain tumor is my own original work and that the printed and electronic literature referred to in it was used in accordance with the international rules of copyright. I understand that in the case of a thesis, it is considered plagiarism when: ● quoting word for word without quotation marks and referring to literature without proper citation. ● referring to content without citing the literature ● presenting previously published ideas of other authors as one’s own. I, the undersigned, declare that I have been informed of the concept of plagiarism. I understand that in case of plagiarism, my thesis will be rejected.(2.27 MB)
Dátum
Szerzők
Folyóirat címe
Folyóirat ISSN
Kötet címe (évfolyam száma)
Kiadó
Absztrakt

We aimed to compare the miRNA expression pattern in malignant tissue samples with lung adenocarcinoma-associated brain tumors and control brain tissue samples from healthy individuals, to develop a miRNA panel that can help reliably distinguish between tumor and healthy samples, potentially serving as biomarkers for adenocarcinoma-associated brain tumors. Two miRNAs, hsa-miR-200c-5p and hsa-miR-141-5p, were identified as significantly upregulated in adenocarcinoma associated brain tumor samples compared to control samples. The identification of hsa-miR-200c-5p and hsa-miR-141-5p as potential biomarkers for lung adenocarcinoma-associated brain tumors opens avenues for early diagnosis of metastatic brain tumors from lung adenocarcinoma and to distinguish it from other brain tumors.

Leírás
Kulcsszavak
lung adenocarcinoma associated brain metastasis, miRNA, biomarker, NGS, RT-qPCR
Forrás
Hivatkozás
https://hdl.handle.net/2437/370892
Gyűjtemények
Theses (Faculty of Medicine)