Szerző szerinti böngészés "Agyare, Eunice"

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    Neuronal Differentiation of mouse embryonic stem cells
    Agyare, Eunice; Szatmári, István; Biochemistry and Molecular Biology; DE--Általános Orvostudományi Kar; Polgár, Zsuzsanna; Orvosi Vegytani Intézet
    The major goal of this study is to differentiate mouse ESCs into neural progenitor cells (NPCs) and investigate the inducibility of a reporter transgene during this neuronal differentiation. I observed that this particular EGFP (enhanced green fluorescence protein) carrying ESC clone (C8) exhibited a very strong transgene inducibility comparing with the other EGFP clones and also this cell clone retained its transgene inducibility upon neural differentiation: 98% of the drug-induced cells were GFP positive after 6 day of differentiation. In addition, I observed that these ESC derived differentiated cells were also able to form neuronal networks and they expressed neural specific genes (Pax6 and Neurog2).