Szerző szerinti böngészés "Cayasso, Mayella Roberta"

Megjelenítve 1 - 1 (Összesen 1)
  • Nincs kép
    TételKorlátozottan hozzáférhető
    Chemotherapeutic Treatment of Advanced Cervical Cancer
    (2014-06-23T14:35:31Z) Cayasso, Mayella Roberta; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József András; Drimba, László; University of Debrecen::Faculty of Pharmacy; Kenézy Kórház, Aneszteziológiai tanszék
    In this day and age, management of advanced, recurrent or persistent cervical cancer includes radiotherapy and chemotherapy. Radiation has been the primary treatment modality for locoregionally advanced cervical cancer. Accompanying systemic cisplatin chemotherapy and radiation have shown high response rates with improvements in long-lasting remissions and overall survival. In this review, we see that cisplatin has been the standard medication for the treatment of advanced cervical cancer, as early as 1985.The top 3 combination treatments were: cisplatin and paclotaxel, followed by cisplatin and gemcibine and topotecan and cisplatin. These achieved increased response and overall survival rates (10.25-12.87 months) and a progression free survival ranging from 4.57- 5.82 months, without further compromising the patients’ quality of life. This review focuses on the mechanism of action and toxicities of the above mentioned drugs, as well as their role as a chemotherapeutic agent in the management of advanced, recurrent, or persistent cervical cancer. Other combination modalities and dosages are also discussed.