In this day and age, management of advanced, recurrent or persistent cervical cancer

includes radiotherapy and chemotherapy. Radiation has been the primary treatment

modality for locoregionally advanced cervical cancer. Accompanying systemic cisplatin

chemotherapy and radiation have shown high response rates with improvements in

long-lasting remissions and overall survival. In this review, we see that cisplatin has

been the standard medication for the treatment of advanced cervical cancer, as early

as 1985.The top 3 combination treatments were: cisplatin and paclotaxel, followed

by cisplatin and gemcibine and topotecan and cisplatin. These achieved increased

response and overall survival rates (10.25-12.87 months) and a progression free survival

ranging from 4.57- 5.82 months, without further compromising the patients’ quality

of life. This review focuses on the mechanism of action and toxicities of the above

mentioned drugs, as well as their role as a chemotherapeutic agent in the management

of advanced, recurrent, or persistent cervical cancer. Other combination modalities and

dosages are also discussed.