Szerző szerinti böngészés "Kim, Yu Rim"

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    Comparative efficacy of statins and non-statin treatment of hyperlipidemia
    Kim, Yu Rim; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet
    Hyperlipidemia, particularly elevated LDL-C, is a key modifiable driver of atherosclerotic cardiovascular disease, making lipid-lowering therapy central to prevention. Statins remain the first-line treatment, backed by strong evidence of LDL-C reduction and decreased cardiovascular morbidity, but many patients either fail to achieve guideline targets or cannot tolerate them. This thesis compares statin monotherapy, statin-plus-non-statin combinations, and non-statin monotherapy, evaluating agents such as ezetimibe, PCSK9 inhibitors, bempedoic acid, and inclisiran. Evidence shows that PCSK9 inhibitors and inclisiran achieve the largest LDL-C reductions when added to statins, while ezetimibe and bempedoic acid provide moderate but meaningful benefits, and non-statins alone serve as important alternatives for statin-intolerant patients. The analysis concludes that personalized, risk-based strategies balancing efficacy, safety, cost, and adherence are essential to optimize lipid management and reduce long-term cardiovascular risk.