Szerző szerinti böngészés "Tolnai, Emese"

Megjelenítve 1 - 3 (Összesen 3)
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    Az emberi faj
    Tolnai, Emese; Nyilas, Istvánné; DE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézet
    A dolgozat az emberi faj főbb felépítését taglalja jellemzi, részletesen kitér az endokrin rendszere, az idegrendszere és a vázizomrendszerünkre. Hormonok működését és hatásukat részletesen taglalja.
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    Mesenchymal Stem Cells: Pioneers in the New Era of Medicine
    Bawab, Faris; Türk-Mázló, Anett; Általános Orvostudományi Kar::Immunológiai Intézet; DE--Általános Orvostudományi Kar; Jambrovics, Károly; Tolnai, Emese; Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet; Egyetemen kívüli
    This thesis explores the evolving landscape and future potential of Mesenchymal Stem Cells (MSCs) in regenerative medicine and therapeutic applications. MSCs, known for their multipotent differentiation capabilities and immunomodulatory properties, have garnered significant interest in the medical and scientific communities. The thesis concludes that while MSCs hold significant promise for advancing regenerative medicine and therapeutic interventions, ongoing research and innovation are essential to overcome current limitations. Strategic collaboration between scientists, clinicians, and regulatory bodies will be crucial in realizing the full potential of MSCs in future medical applications.
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    Study of miRNA expression in invasive aspergillosis
    Nwozor, Kingsley Okechukwu; Paholcsek, Melinda; Tolnai, Emese; Human Genetics; Debreceni Egyetem::Általános Orvostudományi Kar; DE--Általános Orvostudományi Kar; Scholtz, Beáta; Debreceni Egyetem, Általános Orvostudományi Kar; Biokémiai és Molekuláris Biológiai Intézet
    Introduction: miRNAs are key regulators of various physiological and pathophysiological processes and their altered expression levels have been associated to many diseases. Increasing number of evidences have demonstrated that specific miRNAs can serve as novel biomarkers for clinical diagnosis of diseases. Invasive aspergillosis is life-threatening systemic fungal infection. Regrettably, the standard diagnostic methods for this condition take days to produce a reliable result. Objectives: The aim of this study was to probe the expression profiles of 15 selected miRNAs in patients, with fevered neutropenia. We hypothesized that invasive aspergillosis could change the miRNA profiles in the blood. Our goal was to make a rapid test supporting diagnosis of invasive mycoses. Methods: We obtained whole blood samples from 16 patients suffering neutropenic fever and from 5 healthy volunteers without neutropenic fever. Total RNA was isolated from the whole blood and were reverse transcribed to cDNA. TaqMan® quantitative real-time PCR (miRNA assay) was used for detecting miRNA expression profiles. Relative mRNA expressions were calculated with the ΔΔCt method. Results: 7 out of the 19 miRNAs showed significant upregulation in the expression levels at p<0.05. Conclusion: The miRNAs with significantly different expression between the test group and the control can be used as informative biomarkers to assess and monitor the body’s physio-pathological status in invasive aspergillosis.