18F-FDG PET/CT is an imaging modality widely used nowadays in medicine, especially in the field of oncology. My work refers to the usefulness of 18F-FDG PET/CT in the evaluation of Neoadjuvant Chemotherapy in patients with advanced breast cancer. A research was performed, following twenty-nine patients with advanced breast cancer, who have underwent 18F-FDG PET/CT scan at the baseline and afterwards have been treated with Neoadjuvant chemotherapy.