The major public health concern of the 21st century is the rise of chronic non-communicable diseases, in particular coronary heart disease that has been one of the leading cause of death worldwide especially in the Eastern Mediterranean region that has suffered from political instability in many countries of the region. Syria was a small peaceful country in the eastern Mediterranean region where civilization witnessed the birth of the first alphabet; unfortunately from 2011 until now Syria has been going through the largest humanitarian crisis worldwide, and the conflict is engulfing the people, history, and thousands of years of coexistence of cultures. Syria’s health calamity was a direct result of the ongoing war, but also of the failure of international bodies that strive to achieve peace and fulfillment of humankind potential. It is well known that in addition to the direct effects of war such as direct injuries and immigration, indirect effects on social determinants of health have also high level of importance and can result in major health inequalities because of the breakdown of healthcare services, economic instability, and inaccessibility of education. This research aims to analyze the possible indirect effects of the ongoing war in Syria on coronary heart disease main risk factors that are hypertension, smoking, alcohol, obesity, diabetes and raised-total cholesterol and the possible change of prevalence and pattern. The study design applied a survey-based cross-sectional method in an informal neighborhood in Lattakia, Syria; the used questionnaire was a summarized form of the World Health Organization STEPS instrument for non-communicable disease risk factor surveillance. The research applied random sampling from patients’ registries and the final sample was comprised of thirty participants with a response rate of 74.02%. The researcher conducted a face-to-face interview with all study participants. The findings were transferred to a Microsoft Excel worksheet to start the computed analysis of prevalence and association of the studied risk factors with possible demographic and socio-behavioral correlates. The prevalence estimation of hypertension, smoking, and obesity was then compared with a reference data from a research that was conducted in an informal settlement in Aleppo, Syria and represented the situation of coronary heart disease before the war. This comparison was to describe the alteration in the pattern of the risk factors of coronary heart disease in the studied sample. In the analysis, both chi-squared test and multivariate logistic regression were used. The findings of this study showed a high prevalence of hypertension, smoking and obesity and suggested a rising trend of coronary heart disease in Syria. Moreover this research addressed many social outcomes of war that were noticed in low literacy level and economic status of study participants; in addition to low health education and inaccessibility to health care services and medications. Instable mental health was also a very common issue among study participants whom were only living day by day without future dreams or hope. The demonstrated extreme exposure to major risk factors of coronary heart disease forecasts that in the post-war era, Syrians will face the second wave of the health detrimental effect of the war dominated with tremendous health status of the survivors. This study was only a snapshot of the on ground situation of coronary heart disease and further investigations are needed to produce generalizable findings and to set appropriate interventions to tackle this pandemic. To sum up, the human catastrophe of Syria is a result of the failure of the international system for peace and humanitarian assistance hence, international bodies of public health need to take their responsibility on finding solutions to stop this pandemic in Syria.