There are several treatments for the acute pancreatitis. The pharmacological therapies have important role in the pain control, the decreasing the incidence rate of the infectious complications, and the reducing exocrine stimulation. In a consequence, decreasing the mortality and decreasing the total hospital staying are the goals of the therapies. However, some of them have been discussed or still remain controversial. Here are the newly proven effects of the recent pharmacological medication and the recent pharmacological approaches to the acute pancreatitis.